According to World Health Organization (WHO), 80 % of the developing world’s population depends on traditional medicine for primary healthcare. Regulatory agencies and consumer groups are therefore increasingly demanding for stringent quality control measures for global positioning of herbal products. Some of the identified challenges regarding herbal medicine are centered around standardization, safety, adulteration and irrational use. This is largely due to a dearth of skilled manpower in their production and regulation. The African Center of Excellence for Drug Research, Herbal Medicines Development and Regulatory Science (ACEDHARS) was established to build up manpower on quality assurance, standardization of dosages, reproducibility of herbal preparations, drug development, drug repurposing and safety monitoring of drugs in West and Central African region. The researches in the Center are focused on the development and evaluation of herbal formulations into standard products for management of non-communicable diseases (NCDs). The Center is poised to produce a compendium of herbal formulations for the treatment of NCDs in sub-Saharan Africa.