{"id":99,"date":"2024-12-12T08:57:55","date_gmt":"2024-12-12T08:57:55","guid":{"rendered":"http:\/\/localhost\/acedhars\/?page_id=99"},"modified":"2025-04-02T09:41:31","modified_gmt":"2025-04-02T09:41:31","slug":"m-sc-drug-discovery-development","status":"publish","type":"page","link":"https:\/\/acedhars.unilag.edu.ng\/?page_id=99","title":{"rendered":"M.SC DRUG DISCOVERY &amp; DEVELOPMENT"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"99\" class=\"elementor elementor-99\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b5370cf e-con-full e-flex e-con e-parent\" data-id=\"b5370cf\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-364fe0e e-con-full e-flex e-con e-child\" data-id=\"364fe0e\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-86fe360 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1);\r\n}\r\n.btn-style-two .elementor-button{\r\n    -webkit-transform: skew(-12deg);\r\n    transform: skew(-12deg);\r\n    -webkit-transform-origin: bottom left;\r\n    transform-origin: bottom left;\r\n}\r\n.btn-style-two .elementor-button:before{\r\n    background: var(--gradient-1);\r\n    -webkit-transform-origin: top right;\r\n    transform-origin: top right;\r\n}\r\n.btn-style-two:hover .elementor-button:before {\r\n    -webkit-transform-origin: bottom left;\r\n    transform-origin: bottom left;\r\n    -webkit-transform: scale(1, 1);\r\n    transform: scale(1, 1);\r\n}\r\n<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70f223a e-flex e-con-boxed e-con e-parent\" data-id=\"70f223a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ca0ee5b e-con-full e-flex e-con e-child\" data-id=\"ca0ee5b\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f859528 e-con-full e-flex e-con e-child\" data-id=\"f859528\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d31d71c elementor-widget elementor-widget-text-editor\" data-id=\"d31d71c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5>M.Sc. Drug Discovery &amp; Development<\/h5><table border=\"1\" width=\"50%\" align=\"center\"><tbody><tr><td><h2>FOR<\/h2>Admission Requirements<br \/>Graduation Requirements<br \/>List of Courses and No. of Units by Levels in tabular form<br \/>Summary of number of units compulsory and elective coursesl<br \/>Course Contents\/Description<\/td><\/tr><\/tbody><\/table><h5><br \/><br \/><\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-666c7a9 e-con-full e-flex e-con e-child\" data-id=\"666c7a9\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8fb4f77 e-flex e-con-boxed e-con e-parent\" data-id=\"8fb4f77\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-39e0642 elementor-widget elementor-widget-text-editor\" data-id=\"39e0642\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4><em>Master<\/em><em>\u00a0<\/em><em>of<\/em><em>\u00a0<\/em><em>Science<\/em><em>\u00a0<\/em><em>in<\/em><em>\u00a0<\/em><em>Drug<\/em><em>\u00a0<\/em><em>Discovery<\/em><em>\u00a0<\/em><em>and<\/em><em>\u00a0<\/em><em>Development<\/em><em>\u00a0<\/em><em>(Full<\/em><em>\u00a0<\/em><em>Time)<\/em><\/h4><p>About\u00a0the\u00a0Programme<\/p><p>Drug development comprises all the activities involved in transforming a compound from drug candidate (the end-product of the discovery phase) to a product approved for marketing by the appropriate regulatory authorities. The transformation involves a conversion process that commences with\u00a0clinical\u00a0trials\u00a0from\u00a0laboratory\u00a0to\u00a0the\u00a0field\u00a0using\u00a0human\u00a0volunteers\u00a0at\u00a0different\u00a0stages\u00a0to\u00a0evaluate\u00a0the efficacy, dosage and side effects of the discovered drug. The programme will develop capability in effective evaluation of the processes involved in drug development in the pharmaceutical industry, herbal \/traditional medicine sector and for research purposes.<\/p><p>The aim of the programme is to develop knowledge and skills in the science of drug conversion from discovery to development for improvement of human health. Its objectives are:<\/p><ul><li>totrain\u00a0and\u00a0build\u00a0expertise\u00a0in\u00a0all\u00a0the\u00a0specialized\u00a0sections\u00a0involved\u00a0in\u00a0drug\u00a0discovery\u00a0and\u00a0development process<\/li><li>to develop manpower capable of transforming traditional knowledge from ethnobotanical use of herbal medicines into scientifically proven realities acceptable for modern day healthcare development<\/li><li>toprovide\u00a0the\u00a0manpower\u00a0capacity\u00a0for\u00a0research,\u00a0innovation\u00a0and\u00a0teaching\u00a0in\u00a0research\u00a0and\u00a0development section of the healthcare industry, research and academic institutions<\/li><\/ul><p>At\u00a0the\u00a0end\u00a0of\u00a0the\u00a0course,\u00a0students\u00a0should be\u00a0able\u00a0to:<\/p><ul><li>knowthe\u00a0physicochemical\u00a0factors\u00a0which\u00a0affect\u00a0biological\u00a0actions\u00a0of\u00a0drugs<\/li><li>isolateand\u00a0develop\u00a0molecules\u00a0from\u00a0natural sources\u00a0to\u00a0modern\u00a0therapeutic\u00a0products<\/li><li>synthesizedrug\u00a0molecules\u00a0as\u00a0active\u00a0pharmaceutical\u00a0<\/li><li>re-purposeexisting\u00a0drugs\u00a0based\u00a0on\u00a0knowledge\u00a0of\u00a0active\u00a0sites\u00a0and\u00a0disease\u00a0<\/li><li>knowthe\u00a0importance\u00a0of\u00a0pharmaceutical\u00a0analysis\u00a0and\u00a0quality\u00a0control\u00a0of\u00a0pharmaceuticals, agrochemicals and herbal products<\/li><li>knowthe\u00a0role of\u00a0Regulatory\u00a0bodies\u00a0such\u00a0as\u00a0WHO,\u00a0NAFDAC,\u00a0FMOH<\/li><li>understandthe\u00a0effect\u00a0of\u00a0disease\u00a0states\u00a0on\u00a0drug\u00a0plasma\u00a0levels\u00a0and\u00a0therapeutic\/toxic\u00a0responses<\/li><li>understandthe factors\u00a0that\u00a0affect\u00a0stability\u00a0of\u00a0drugs\u00a0and\u00a0how\u00a0to\u00a0determine shelf\u00a0lives\u00a0of\u00a0drugs<\/li><li>understand the knowledge of Pharmacokinetics, spectroscopic and chromatographic techniques in drug development.<\/li><\/ul><h4><strong><em><b><i>Admission<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>Requirements<\/i><\/b><\/em><\/strong><\/h4><p><strong><em>\u00a0<\/em><\/strong>Admission into the M.Sc. Drug Development Programme is open to candidates who possess credit passes in English, Mathematics, Physics, Chemistry and Biology in \u2018O\u2019 level or its equivalent at one sitting and a minimum of Second-class Lower Bachelor\u2019s degree in Pharmacy, Pharmacology, Physiology, Biochemistry, Biotechnology, Chemistry and Chemical Engineering from any Nigerian recognized University or a foreign qualification of an equivalent standard.<\/p><p><strong><em><b><i>Graduation<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>Requirements<\/i><\/b><\/em><\/strong><\/p><p>To obtain\u00a0an M.Sc. in Drug Development, a candidate must\u00a0satisfy a minimum of\u00a0<strong>24 units <\/strong>of courses in\u00a0minimum\u00a0of\u00a0two\u00a0(2)\u00a0semesters\u00a0and\u00a0with\u00a0cumulative\u00a0grade\u00a0point\u00a0average\u00a0(CGPA)\u00a0of\u00a02.40\u00a0at\u00a0800\u00a0level made up as follows:<\/p><ol><li>14units\u00a0of\u00a0compulsory\u00a0theory\u00a0courses<\/li><li>2units\u00a0of\u00a0research\u00a0seminar<\/li><\/ol><ul><li>4units\u00a0of\u00a0research\u00a0project<\/li><\/ul><ol><li>4units\u00a0of\u00a0elective\u00a0courses<\/li><\/ol><p>The duration of the programme shall be minimum of two (2) semesters and maximum of four (4) semesters.<\/p><p><strong><em><b><i>List<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>of<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>Courses<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>and<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>No<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>of<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>Units<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>by<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>Levels<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>in<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>tabular<\/i><\/b><\/em><\/strong><strong><em><b><i>\u00a0<\/i><\/b><\/em><\/strong><strong><em><b><i>form<\/i><\/b><\/em><\/strong><\/p><table><tbody><tr><td colspan=\"4\" width=\"605\"><p><strong>800<\/strong><strong>\u00a0<\/strong><strong>LEVEL<\/strong><strong>\u00a0\u00a0<\/strong><strong>FIRST<\/strong><strong>\u00a0<\/strong><strong>SEMESTER<\/strong><\/p><\/td><\/tr><tr><td width=\"75\"><p><strong>COURSE<\/strong><\/p><p><strong>CODE<\/strong><\/p><\/td><td width=\"365\"><p><strong>COURSE<\/strong><strong>\u00a0<\/strong><strong>TITLE<\/strong><\/p><\/td><td width=\"92\"><p><strong>STATUS<\/strong><\/p><\/td><td width=\"71\"><p><strong>UNITS<\/strong><\/p><\/td><\/tr><tr><td width=\"75\"><p>DDD\u00a0811<\/p><\/td><td width=\"365\"><p>Advanced\u00a0Organic\u00a0Chemistry\u00a0and\u00a0drug\u00a0development.<\/p><\/td><td width=\"92\"><p>Compulsory<\/p><\/td><td width=\"71\"><p>2<\/p><\/td><\/tr><tr><td width=\"75\"><p>DDD\u00a0812<\/p><\/td><td width=\"365\"><p>Bioassay\u00a0methods\u00a0in\u00a0Natural\u00a0Product\u00a0Research<\/p><\/td><td width=\"92\"><p>Compulsory<\/p><\/td><td width=\"71\"><p>2<\/p><\/td><\/tr><tr><td width=\"75\"><p>TOX 811<\/p><\/td><td width=\"365\"><p>Biochemical\u00a0and\u00a0Molecular\u00a0Toxicology<\/p><\/td><td width=\"92\"><p>Compulsory<\/p><\/td><td width=\"71\"><p>2<\/p><\/td><\/tr><tr><td width=\"75\"><p>PUH\u00a0801<\/p><\/td><td width=\"365\"><p>Medical Statistics<\/p><\/td><td width=\"92\"><p>Compulsory<\/p><\/td><td width=\"71\"><p>2<\/p><\/td><\/tr><tr><td width=\"75\"><p>PHA\u00a0800<\/p><\/td><td width=\"365\"><p>Pharmacokinetics<\/p><\/td><td width=\"92\"><p>Compulsory<\/p><\/td><td width=\"71\"><p>2<\/p><\/td><\/tr><tr><td width=\"75\"><p>PCH\u00a0801<\/p><\/td><td width=\"365\"><p>Drug\u00a0Quality\u00a0Assurance\u00a0and\u00a0Total\u00a0Quality\u00a0Management<\/p><\/td><td width=\"92\"><p>Compulsory<\/p><\/td><td width=\"71\"><p>2<\/p><\/td><\/tr><tr><td width=\"75\"><p>DDD\u00a0813<\/p><\/td><td width=\"365\"><p>Extraction\u00a0and\u00a0Isolation\u00a0Techniques\u00a0in Natural\u00a0Product<\/p><\/td><td width=\"92\"><p>Elective<\/p><\/td><td width=\"71\"><p>2<\/p><\/td><\/tr><tr><td width=\"75\"><p>PCG\u00a0803<\/p><\/td><td width=\"365\"><p>Advanced\u00a0phytochemistry<\/p><\/td><td width=\"92\"><p>Elective<\/p><\/td><td width=\"71\"><p>3<\/p><\/td><\/tr><tr><td width=\"75\"><p>PCG\u00a0802<\/p><\/td><td width=\"365\"><p>Pharmaceutical\u00a0Analysis\u00a0of\u00a0Natural\u00a0Product<\/p><\/td><td width=\"92\"><p>Elective<\/p><\/td><td width=\"71\"><p>2<\/p><\/td><\/tr><tr><td width=\"75\"><p>\u00a0<\/p><\/td><td width=\"365\"><p><strong>Total<\/strong><strong>\u00a0<\/strong><strong>units<\/strong><\/p><\/td><td width=\"92\"><p><strong>Compulsory<\/strong><\/p><\/td><td width=\"71\"><p><strong>12<\/strong><\/p><\/td><\/tr><tr><td width=\"75\"><p>\u00a0<\/p><\/td><td width=\"365\"><p>\u00a0<\/p><\/td><td width=\"92\"><p><strong>Elective<\/strong><\/p><\/td><td width=\"71\"><p><strong>7<\/strong><\/p><\/td><\/tr><\/tbody><\/table><p>\u00a0<\/p><table><tbody><tr><td colspan=\"4\" width=\"605\"><p><strong>800<\/strong><strong>\u00a0<\/strong><strong>LEVEL<\/strong><strong>\u00a0<\/strong><strong>SECOND<\/strong><strong>\u00a0<\/strong><strong>SEMESTER<\/strong><\/p><\/td><\/tr><tr><td width=\"85\"><p><strong>COURSE <\/strong><strong>CODE<\/strong><\/p><\/td><td width=\"324\"><p><strong>COURSE<\/strong><strong>\u00a0<\/strong><strong>TITLE<\/strong><\/p><\/td><td width=\"121\"><p><strong>STATUS<\/strong><\/p><\/td><td width=\"74\"><p><strong>UNITS<\/strong><\/p><\/td><\/tr><tr><td width=\"85\"><p>DDD\u00a0828<\/p><\/td><td width=\"324\"><p>Research\u00a0Seminar<\/p><\/td><td width=\"121\"><p>Compulsory<\/p><\/td><td width=\"74\"><p>2<\/p><\/td><\/tr><tr><td width=\"85\"><p>DDD\u00a0829<\/p><\/td><td width=\"324\"><p>Research\u00a0Project<\/p><\/td><td width=\"121\"><p>Compulsory<\/p><\/td><td width=\"74\"><p>4<\/p><\/td><\/tr><tr><td width=\"85\"><p>PCH\u00a0805<\/p><\/td><td width=\"324\"><p>Laboratory\u00a0Course\u00a0in\u00a0Pharmaceutical\u00a0Chemistry\u00a0II<\/p><\/td><td width=\"121\"><p>Compulsory<\/p><\/td><td width=\"74\"><p>2<\/p><\/td><\/tr><tr><td width=\"85\"><p>DDD\u00a0821<\/p><\/td><td width=\"324\"><p>Advanced\u00a0Bioactive\u00a0Compounds\u00a0of\u00a0Natural\u00a0Sources<\/p><\/td><td width=\"121\"><p>Elective<\/p><\/td><td width=\"74\"><p>1<\/p><\/td><\/tr><tr><td width=\"85\"><p>DDD\u00a0822<\/p><\/td><td width=\"324\"><p>Natural\u00a0Drug\u00a0Lead\u00a0Development\u00a0(Nano\u00a0medicine)<\/p><\/td><td width=\"121\"><p>Elective<\/p><\/td><td width=\"74\"><p>2<\/p><\/td><\/tr><tr><td width=\"85\"><p>DDD\u00a0823<\/p><\/td><td width=\"324\"><p>Drug\u00a0metabolism<\/p><\/td><td width=\"121\"><p>Elective<\/p><\/td><td width=\"74\"><p>2<\/p><\/td><\/tr><tr><td width=\"85\"><p>PCG\u00a0805<\/p><\/td><td width=\"324\"><p>Biological\u00a0variation\u00a0in\u00a0Natural\u00a0Product<\/p><\/td><td width=\"121\"><p>Elective<\/p><\/td><td width=\"74\"><p>2<\/p><\/td><\/tr><tr><td width=\"85\"><p>PCG\u00a0806<\/p><\/td><td width=\"324\"><p>Cultivation, Conservation &amp; Biodiversity of<\/p><p>Medicinal\u00a0Plants<\/p><\/td><td width=\"121\"><p>Elective<\/p><\/td><td width=\"74\"><p>2<\/p><\/td><\/tr><tr><td width=\"85\"><p>CHM\u00a0844<\/p><\/td><td width=\"324\"><p>Advanced\u00a0Natural\u00a0Products<\/p><\/td><td width=\"121\"><p>Elective<\/p><\/td><td width=\"74\"><p>3<\/p><\/td><\/tr><tr><td width=\"85\"><p>\u00a0<\/p><\/td><td width=\"324\"><p><strong>Total<\/strong><strong>\u00a0<\/strong><strong>Units<\/strong><\/p><\/td><td width=\"121\"><p><strong>Compulsory<\/strong><\/p><\/td><td width=\"74\"><p><strong>8<\/strong><\/p><\/td><\/tr><tr><td width=\"85\"><p>\u00a0<\/p><\/td><td width=\"324\"><p>\u00a0<\/p><\/td><td width=\"121\"><p><strong>Elective<\/strong><\/p><\/td><td width=\"74\"><p><strong>12<\/strong><\/p><\/td><\/tr><\/tbody><\/table><p><strong><em>Summary<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>of<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>number<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>of<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>units<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>compulsory<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>and<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>elective<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>courses<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>to<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>be<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>taken\/available<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>at each <\/em><\/strong><strong><em>Level<\/em><\/strong><\/p><table><tbody><tr><td width=\"48\"><p>\u00a0<\/p><\/td><td colspan=\"2\" width=\"150\"><p><strong>First<\/strong><strong>\u00a0<\/strong><strong>semester<\/strong><\/p><\/td><td colspan=\"2\" width=\"150\"><p><strong>Second<\/strong><strong>\u00a0<\/strong><strong>semester<\/strong><\/p><\/td><td colspan=\"2\" width=\"146\"><p><strong>Total<\/strong><\/p><\/td><\/tr><tr><td width=\"48\"><p><strong>Level<\/strong><\/p><\/td><td width=\"82\"><p>Units of\u00a0Compulsory Courses<\/p><\/td><td width=\"68\"><p>Units of\u00a0Elective Courses<\/p><p>Available<\/p><\/td><td width=\"82\"><p>Units of\u00a0Compulsory Courses<\/p><\/td><td width=\"68\"><p>Units of\u00a0Elective Courses<\/p><p>Available<\/p><\/td><td width=\"80\"><p>Total of\u00a0Compulsory Courses<\/p><\/td><td width=\"66\"><p>Total of\u00a0Elective Courses<\/p><p>Available<\/p><\/td><\/tr><tr><td width=\"48\"><p><strong>800<\/strong><\/p><\/td><td width=\"82\"><p><strong>12<\/strong><\/p><\/td><td width=\"68\"><p><strong>7<\/strong><\/p><\/td><td width=\"82\"><p><strong>8<\/strong><\/p><\/td><td width=\"68\"><p><strong>12<\/strong><\/p><\/td><td width=\"80\"><p><strong>20<\/strong><\/p><\/td><td width=\"66\"><p><strong>19<\/strong><\/p><\/td><\/tr><\/tbody><\/table><p><strong><em>\u00a0<\/em><\/strong><em>Course<\/em><em>\u00a0<\/em><em>Contents\/Description<\/em><\/p><p><strong><b>DDD<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>811:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Advanced<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Organic<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Chemistry<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>and<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Drug<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Development<\/b><\/strong><\/p><p>Theoretical\u00a0descriptions\u00a0of\u00a0organic\u00a0molecules.\u00a0The\u00a0different\u00a0approaches\u00a0in\u00a0the\u00a0determination\u00a0of\u00a0organic reaction mechanisms, physical organic chemical principles and reaction mechanisms that rationalize drug\u00a0actions, Quantitative\u00a0structure\u00a0and\u00a0reactivity\u00a0relationship\u00a0in\u00a0organic\u00a0reactions.\u00a0Isosterism\u00a0and\u00a0drug discovery, selected organic reactions used for drug discovery and modulations of bioactivity- Fluorination,\u00a0Heteroatom\u00a0alkylation,\u00a0Carbon\u00a0Coupling,\u00a0Making\u00a0and\u00a0modification\u00a0of\u00a0heterocycles,\u00a0Atom swapping.<\/p><p><strong><b>DDD<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>812:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Bioassay<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Methods<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>in<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Natural<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Products<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Research<\/b><\/strong><\/p><p>Introduction to qualitative or quantitative biological screening methods used in evaluation of the pharmacological effect or potency of natural products (in vivo, in vitro, ex vivo):\u00a0Common tropical diseases such as antimalarial (parasitic) assay, antimicrobial assays, anthelmintic activity assays, anti- inflammatory assay, analgesic assays and antiviral and anticancer assays, hepatotoxicity assays, immunomodulating assay, antiepileptic (anticonvulsant) assay, antiulcer assays, antimicrobial assays, anti-emetic assay, toxicity assays<\/p><p><strong><b>DDD<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>813:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Extraction<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>and<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Isolation<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Techniques<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>for<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Natural<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Products<\/b><\/strong><\/p><p>Extraction techniques: Introduction to basic separation methods for various plant metabolites: Maceration, Soxhlet extraction, percolation, decoction, hydro distillation and steam distillation, pressurized liquid extraction, microwave assisted extraction, supercritical fluid extraction, ultrasound assisted extraction, reflux extraction, pulsed electric field extraction, enzyme assisted extraction. Factors\u00a0affecting\u00a0extraction\u00a0procedures:\u00a0Polarity\u00a0of solvent, extraction\u00a0duration, solvent to\u00a0solid ration, surface chemistry, particle size, temperature etc. Separation\/isolation techniques: Introduction, principle,\u00a0methods,\u00a0instrumentation\u00a0and\u00a0application\u00a0of\u00a0separation\u00a0techniques\u00a0in\u00a0natural\u00a0product\u00a0isolation procedures of bioactive compounds: Thin Layer chromatography (TLC), high performance liquid chromatography (HPLC), column chromatography, flash chromatography, vacuum-liquid chromatography, high performance thin layer chromatography (HPTLC), capillary electrophoresis, ultra-high performance liquid chromatography, gas chromatography, gas-liquid chromatography, ion exchange chromatography, droplet counter current chromatography, affinity chromatography, gel chromatography etc.<\/p><p><strong><b>DDD<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>821:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Advanced<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Bioactive<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Organic<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Compounds<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>of<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Natural<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Sources<\/b><\/strong><\/p><p>A study of natural organic compounds used for the cure, mitigation or prevention of diseases- Natural Product Pharmaceuticals. A series of case studies on blockbuster drugs from natural products will be used to illustrate various aspects of the drug discovery process, Examples to include drugs such as Artemisinin, Prozac, Taxol etc.\u00a0Naturally occurring insecticidal agents including pheromone. Challenges and opportunities in drug discovery from plants.<\/p><p><strong>DDD<\/strong><strong>\u00a0<\/strong><strong>822:<\/strong><strong>\u00a0<\/strong><strong>Natural<\/strong><strong>\u00a0<\/strong><strong>Drug<\/strong><strong>\u00a0<\/strong><strong>Lead<\/strong><strong>\u00a0<\/strong><strong>Development<\/strong><strong>\u00a0<\/strong><strong>(Nano<\/strong><strong>\u00a0<\/strong><strong>medicine)<\/strong><\/p><p>Course examines phytochemicals of natural origin including their distribution, roles in human health promotion,\u00a0biosynthesis\u00a0and\u00a0degradation.\u00a0Phytochemicals\u00a0\u2013\u00a0functional\u00a0roles;\u00a0assays\u00a0for\u00a0total\u00a0antioxidant activity of ascorbic acid, organic acids, Phenolics, flavonoids, Anthocyanins; Flavonols and flavones, Tannins, Quinone Pigments, Diterpenes and gibberellins, Triterpenes and steroids; Carotenoids, Glucosinolates,\u00a0Lipids\u00a0and Waxes,\u00a0Amines\u00a0and\u00a0alkaloids,\u00a0Sulphur\u00a0amino\u00a0acids,\u00a0Cyanogenic\u00a0glycosides and seed Storage proteins,\u00a0Principles of functional foods and nutraceutical concepts, involving conventional\u00a0nutrients\u00a0and\u00a0phytochemicals,\u00a0health\u00a0claims\u00a0and\u00a0evidence\u00a0\u2013\u00a0based\u00a0potentials,\u00a0toxicological implications, regulation and consumer trends.<\/p><p><strong><b>DDD<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>823:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Drug<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Metabolism<\/b><\/strong><\/p><p>Xenobiotics metabolism; biotransformation reactions (phases I &amp; II); toxicity and toxicology terms &amp; concepts;\u00a0dose-response\u00a0curves;\u00a0classification\u00a0of\u00a0metabolites;\u00a0microsomal\u00a0and\u00a0non-microsomal\u00a0enzyme systems; monooxygenases and mixed function oxidases-cytochrome P450\u00a0family; induction and inhibition of drug metabolism; factors influencing drug metabolism; mechanisms of drug toxicity; theories of the mechanism of drug action, Drug resistance and factors affecting drug efficacy, The physiological and biochemical action of some selected drugs to reflect excellence. Medicinal plants in the management\u00a0and\u00a0therapy\u00a0of common\u00a0ailments- malaria, sickle\u00a0cell anemia,\u00a0common\u00a0cold, hepatitis<\/p><p><strong><b>DDD<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>828:Research<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Seminars<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>in<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Toxicology<\/b><\/strong><\/p><p>Presentations\u00a0by\u00a0students\u00a0on\u00a0systemic,\u00a0environmental\u00a0and\u00a0forensic\u00a0toxicology<\/p><p><strong><b>DDD<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>829Research<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Project<\/b><\/strong><\/p><p>Research\u00a0on\u00a0toxicological\u00a0issues<\/p><p><strong><b>TOX<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>811:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Biochemical<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>and<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Molecular<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Toxicology<\/b><\/strong><\/p><p>An outline of the basics of molecular biology, drug\/receptor interactions, receptors and ion channels, regulation of second messengers and drug metabolism. Biochemical and molecular actions of environmental chemicals and toxicants, and assessment of cellular damage by biochemical measurements and other state-of-the-art technologies. Biochemical and molecular mechanisms of drug\/chemical toxicities.<\/p><p><strong><b>PUH<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>801:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Medical<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Statistics<\/b><\/strong><\/p><p>Design, conduct\u00a0and\u00a0interpretation\u00a0of\u00a0clinical\u00a0and\u00a0epidemiological studies, standard\u00a0statistical concepts of\u00a0data\u00a0descriptions,\u00a0hypothesis\u00a0testing\u00a0including\u00a0test\u00a0statistics,\u00a0correlation,\u00a0p-values,\u00a0significance\u00a0levels, confidence levels and linear regression.<\/p><p><strong><b>PHA 800:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Pharmacokinetics<\/b><\/strong><\/p><p>Introduction; The LADME system- Drug liberation, absorption, distribution and excretion; Drug metabolism and biotransformation; Drug-receptor interaction, binding energy, drug receptor theories, pKa and pharmacokinetics; Determination\u00a0of\u00a0fraction\u00a0of\u00a0drug\u00a0absorbed in\u00a0stomach\u00a0and gastrointestinal tract; Determination of rate constants- Kel (elimination rate constant), Kab (absorption rate constant); Experimental design of pharmacokinetic studies and compartmental models; Bioavailability and bioequivalent studies, Area Under Curve (AUC); Clinical trial of drugs- Branded vs. Generic; Plasma protein binding of drug; Analytical methods for drugs in plasma- Spectrophotometric, HPLC, Gas chromatography; Cumulative urinary excretion and pharmacokinetics in special groups- children, elderly, organ dysfunction and obese patients.<\/p><p><strong><b>PCH<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>801:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Drug<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Quality<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Assurance<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>and<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Total<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Quality<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Management<\/b><\/strong><\/p><p>The importance of Quality Control of Pharmaceuticals, Veterinary medicines and Agrochemicals, Personnel,\u00a0facilities\u00a0and\u00a0Documentation,\u00a0Standard\u00a0Operating\u00a0Procedures\u00a0(SOPs),\u00a0Pharmacopoeia<\/p><p>Monographs\u00a0(USP,\u00a0BP,\u00a0BPC,\u00a0EuP\u00a0etc.).\u00a0Relevant\u00a0equipment\u00a0and\u00a0manuals\u00a0needed\u00a0to\u00a0establish\u00a0a\u00a0standard Drug Quality Control Laboratory; Regulatory Aspects of Drug and Chemicals: Quality Control, Functions of Regulatory bodies such as WHO, NAFDAC, PCN, PGMAN, FMOH, IPAN etc. Total Quality\u00a0Management (TQM). Quantitative Aspects\u00a0of Pharmaceutical Analysis: Acid-\u00a0Base titrimetry, Redox titrimetry, Gravimetry, Separation Techniques \u2013 Extraction Methods and Chromatography (TLC,CC, HPLC, GC, GC\/MS, Super Critical Fluid Chromatograph), Electrochemistry Capillary Electrophoresis, UV\/Visible Spectroscopy, Fluorescence\/Phosphorescence, Atomic Absorption Spectroscopy (AAS), Validation of Analytical procedures.<\/p><p><strong><b>PCH<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>805:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Laboratory<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Course<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>in<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Pharmaceutical<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Chemistry<\/b><\/strong><\/p><p>Pharmaceutical Analysis of Drug Substances, Pharmaceutical preparations, medicinal and allied preparations, Synthesis and characterization of medicinal compounds<\/p><p><strong><b>PCG<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>802:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Pharmaceutical<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Analysis<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>of<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Natural<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Drug <\/b><\/strong><strong><b>Products<\/b><\/strong><\/p><p>Extraction efficiency and purification methods: Chromatographic, biosynthetic techniques, advanced treatment\u00a0of\u00a0chromatographic\u00a0techniques\u00a0(Adsorption\u00a0CC,\u00a0TLC,\u00a0VLC),\u00a0Partition\u00a0(PC,\u00a0GC,\u00a0etc.),\u00a0HPLC, Gel Filtration, electrophoresis, ion-exchange separation, Droplet counter current (DCCC) e.tc. Titrimetric and gravimetric methods. Modern Instrumental methods in structure elucidation (e.g. UV\/Visible, IR, NMR,\u00a0Mass\u00a0Spectroscopy). Assessment of purity, quantification\u00a0and derivatization of natural products<\/p><p><strong><b>PCG<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>803:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Advanced<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Phytochemistry<\/b><\/strong><\/p><p>Advanced\u00a0phytochemistry\u00a0of\u00a0the\u00a0following\u00a0groups\u00a0(i.e.\u00a0Natural\u00a0sources,\u00a0biosynthesis,\u00a0study\u00a0of\u00a0isolation, chemical properties, and bioactivities) of alkaloids, terpenoids (mono-, sesqui-, diester, tri and tetraterpenoids), carotenolides, butadeinolides, anthraquinones,\u00a0flavonoids and other groups.<\/p><p><strong><b>PCG<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>805:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Biological<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Variations<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>in<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Natural<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Products<\/b><\/strong><\/p><p>Biovariation of secondary metabolites, genetic factors (chromosomes, mutation, polyploidy, hybridization,\u00a0chemical races)\u00a0regulatory\u00a0mechanisms\u00a0in\u00a0biochemical\u00a0systems,\u00a0Effect\u00a0of\u00a0the\u00a0enzyme\u00a0on chemical constituents\u00a0and\u00a0drug\u00a0activity\u00a0e.g. oxidoreductases\u00a0of flavonoids, opium\u00a0tea fermentation\u00a0and hydrolases of cardiac and cyanogenetic glycosides.<\/p><p><strong><b>PCG<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>806:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Cultivation,<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Conservation<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>and<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Biodiversity<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>of<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Medicinal<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Plants<\/b><\/strong><\/p><p>Historical developments of cultivated plants. Drug plant propagation techniques examples from common drugs e.g. Digitalis, Opium, Ginger, Cannabis, Nutmeg, (etc.). Development of cultivation, Propagation and Conservation Methods for established Nigerian Medicinal Plants (e.g. those in the African Pharmacopoeia) as raw materials. Factors affecting plant growth e.g. environmental factors, growth hormones etc. Phenotypic effects on variation during cultivation, tissue culture of medicinal plants, possibilities and prospects of drug plant production in Nigeria- economic factors, genetic consideration and selection\u00a0in plant breeding, study of the different factors affecting collection,\u00a0drying and storage of crude drugs. Conservation techniques, environmental implications, biological and biocultural diversities.<\/p><p><strong><b>CHM<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>844:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Advanced<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Natural<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>Products<\/b><\/strong><\/p><p>Selected topics\u00a0in\u00a0Natural\u00a0Products\u00a0Biosynthesis, Microbial\u00a0and\u00a0Insect\u00a0chemistry, marine natural products. Lichen and bryophyte products<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>HOME APPLY NOW M.Sc. Drug Discovery &amp; Development FOR Admission RequirementsGraduation RequirementsList of Courses and No. of Units by Levels in tabular formSummary of number of units compulsory and elective courseslCourse Contents\/Description Master\u00a0of\u00a0Science\u00a0in\u00a0Drug\u00a0Discovery\u00a0and\u00a0Development\u00a0(Full\u00a0Time) About\u00a0the\u00a0Programme Drug development comprises all the activities involved in transforming a compound from drug candidate (the end-product of the discovery phase) to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-99","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/acedhars.unilag.edu.ng\/index.php?rest_route=\/wp\/v2\/pages\/99","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/acedhars.unilag.edu.ng\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/acedhars.unilag.edu.ng\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/acedhars.unilag.edu.ng\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/acedhars.unilag.edu.ng\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=99"}],"version-history":[{"count":19,"href":"https:\/\/acedhars.unilag.edu.ng\/index.php?rest_route=\/wp\/v2\/pages\/99\/revisions"}],"predecessor-version":[{"id":1630,"href":"https:\/\/acedhars.unilag.edu.ng\/index.php?rest_route=\/wp\/v2\/pages\/99\/revisions\/1630"}],"wp:attachment":[{"href":"https:\/\/acedhars.unilag.edu.ng\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=99"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}